Herder risk model
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At the time the article was created David Little had no recorded disclosures.View David Little's current disclosures
At the time the article was last revised Henry Knipe had no recorded disclosures.View Henry Knipe's current disclosures
British Thoracic Society (BTS) guidelines for pulmonary nodules1 recommend the application of the Herder risk model in predicting malignancy in pulmonary nodules.
The Herder model 2 predicts the risk of malignancy in solid pulmonary nodules using patient characteristics, nodules characteristics, and the degree of FDG uptake on PET-CT.
Using the Herder model, pulmonary nodule FDG uptake is classified into four categories. Herder et al did not suggest specific objective values for each level, however, other studies have ref. The BTS recommend using the following scale:
- no uptake: uptake indiscernible from background lung tissue
- faint uptake: uptake less than or equal to mediastinal blood pool
- moderate uptake: uptake greater than mediastinal blood pool
- intense uptake: uptake markedly greater than mediastinal blood pool (not strictly defined but 3x mediastinal blood pool would be considered intense)
- 1. Callister ME, Baldwin DR, Akram AR et-al. British Thoracic Society guidelines for the investigation and management of pulmonary nodules. Thorax. 2015;70 Suppl 2 (Suppl 2): ii1-ii54. doi:10.1136/thoraxjnl-2015-207168 - Pubmed citation
- 2. Herder G, Herder vTH, Herder GR, Herder KP, Herder CE, Herder SE, Herder HO, Herder. Clinical Prediction Model to Characterize Pulmonary Nodules: Validation and Added Value of 18F-fluorodeoxyglucose Positron Emission Tomography. (2005) Chest. doi:10.1378/chest.128.4.2490 - Pubmed