Hereditary renal cancer syndromes

Despite the vast majority of renal cancers being sporadic, there are a number of hereditary renal cancer syndromes:

• von Hippel Lindau syndrome: predominantly clear cell type
• tuberous sclerosis: predominantly clear cell type (also associated with angiomyolipoma)
• hereditary paraganglioma-pheochromocytoma syndromes: predominantly clear cell type
• hereditary papillary renal cell carcinoma: papillary type 1
• hereditary leiomyomatosis and renal cell carcinoma: predominantly papillary type 2
• Birt-Hogg-Dubé syndrome: predominantly chromophobe type, oncocytoma, or a hybrid of both
• hereditary non-polyposis colon cancer (Lynch type II): predominantly upper tract urothelial carcinoma
• sickle cell trait trait or hemoglobinhaemoglobin SC disease: renal medullary carcinoma
• hereditary renal oncocytoma: oncocytoma

See also

• renal cell carcinoma