Hereditary spastic paraplegia

Hereditary spastic paraplegia (HSP) refers to a heterogeneous group of neurodegenerative conditions characterized by progressive degeneration of the corticospinal tracts and posterior column of the spinal cord.

Patients often tend to have progressive lower extremity weakness and spasticity.

Most carry an autosomal recessive inheritance.

Often non-specific and variable but can include:

Article information

rID: 42174
Synonyms or Alternate Spellings:
  • Hereditary spastic paraplegia (HSP)
  • Hereditary spastic paraplegias

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Cases and figures

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