Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Yap J, Knipe H, et al. High attenuation lymphadenopathy. Reference article, Radiopaedia.org (Accessed on 19 Mar 2024) https://doi.org/10.53347/rID-8867
High attenuation lymphadenopathy or adenopathy variably refers to abnormal lymph nodes with attenuation on CT usually higher compared to muscle, either on a noncontrast exam or following contrast administration (i.e. hyperenhancement) 5.
Differential diagnosis
High attenuation nodes may be due to calcifications or other inorganic material:
Hypervascular metastatic and lymphoproliferative disorders can cause high attenuation lymphadenopathy due to intranodal hemorrhage (on unenhanced CT) or hyperenhancement (on contrast-enhanced CT):
Rarely, high attenuation lymphadenopathy has been described due to keratinization of metastatic squamous cell carcinoma of the head and neck 9,10.
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See also
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1. Herts B, Megibow A, Birnbaum B, Kanzer G, Noz M. High-Attenuation Lymphadenopathy in AIDS Patients: Significance of Findings at CT. Radiology. 1992;185(3):777-81. doi:10.1148/radiology.185.3.1438762 - Pubmed
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2. Sharma A, Fidias P, Hayman L, Loomis S, Taber K, Aquino S. Patterns of Lymphadenopathy in Thoracic Malignancies. Radiographics. 2004;24(2):419-34. doi:10.1148/rg.242035075 - Pubmed
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3. Silvers A, Som P, Meyer R. Egg Shell Nodal Calcification in a Patient with Sinus Histiocytosis with Massive Lymphadenopathy Treated with Interferon. AJNR Am J Neuroradiol. 1996;17(2):361-3. PMC8338368 - Pubmed
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4. Helvie M, Rebner M, Sickles E, Oberman H. Calcifications in Metastatic Breast Carcinoma in Axillary Lymph Nodes. AJR Am J Roentgenol. 1988;151(5):921-2. doi:10.2214/ajr.151.5.921 - Pubmed
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5. Glazer H, Molina P, Siegel M, Sagel S. High-Attenuation Mediastinal Masses on Unenhanced CT. AJR Am J Roentgenol. 1991;156(1):45-50. doi:10.2214/ajr.156.1.1898569 - Pubmed
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6. Som P. Detection of Metastasis in Cervical Lymph Nodes: CT and MR Criteria and Differential Diagnosis. AJR Am J Roentgenol. 1992;158(5):961-9. doi:10.2214/ajr.158.5.1566697 - Pubmed
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7. Cao M, Hoyt A, Bassett L. Mammographic Signs of Systemic Disease. Radiographics. 2011;31(4):1085-100. doi:10.1148/rg.314105205 - Pubmed
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8. Fukuda T, Takao M, Uchida T, Iwanaga S, Hayashi K, Okimoto T. High Attenuation Lymphadenopathy Caused by Amyloidosis. Br J Radiol. 1997;70(830):213-4. doi:10.1259/bjr.70.830.9135452 - Pubmed
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9. Hayashi T, Tanaka R, Taira S, Koyama J, Katsura K, Kobayashi F. Non-Contrast-Enhanced CT Findings of High Attenuation Within Metastatic Cervical Lymph Nodes in Patients with Stage I or II Tongue Carcinoma During a Follow-Up Period. AJNR Am J Neuroradiol. 2003;24(7):1330-3. PMC7973692 - Pubmed
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10. Nakayama E, Ariji E, Shinohara M, Yoshiura K, Miwa K, Kanda S. Computed Tomography Appearance of Marked Keratinization of Metastatic Cervical Lymph Nodes: A Case Report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84(3):321-6. doi:10.1016/s1079-2104(97)90351-6 - Pubmed
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11. Karandikar A, Gummalla K, Loke S, Goh J, Tan T. Approach to Intensely Enhancing Neck Nodes. Diagn Interv Radiol. 2016;22(2):168-72. doi:10.5152/dir.2015.14561 - Pubmed
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