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High-grade appendiceal mucinous neoplasms

High-grade appendiceal mucinous neoplasms (HAMN) are rare mucinous tumors of the appendix showing high-grade cytologic atypia, cf. low-grade appendiceal mucinous neoplasms (LAMN). The distinction between both LAMN and HAMN is done on histological grounds and these tumors look the same on imaging. Please, refer to the LAMN article for a detailed conjoined discussion on their imaging findings. 


Considerable controversy still exists on mucinous neoplasms of the appendix pathologic classification and nomenclature 3. According to a panel of specialist review in 2016, a new nomenclature and classification for the appendiceal mucinous neoplasms based on their histologic type and biologic behavior has been proposed, which now includes the “high-grade appendiceal mucinous neoplasm”. The HAMN was proposed to include the lesions that have high-grade atypia and thus cannot be grouped as a LAMN, but also do not have the infiltrative invasion to be characterized as an appendiceal mucinous adenocarcinoma 1,2.


Histologically these tumors show high-grade cytologic atypia associated with at least one of the following 1,2

  • loss of the muscularis mucosae 
  • fibrosis of the submucosa
  • rupture of the appendix
  • mucin and/or tumoral cells outside the appendix

Article information

rID: 54956
Synonyms or Alternate Spellings:
  • High-grade appendiceal mucinous neoplasms (HAMN)
  • HAMN

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