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Histiocytic sarcoma is a rare malignant hematopoietic neoplasm that has been reported in association with other hematological malignancies (particularly B and T cell lymphomas).
It comprises of tumor cells derived from the monocyte/macrophage lineage.
It usually occurs in lymph nodes, skin, and the gastrointestinal tract. Occurrence in the CNS system has also been rarely reported 3.
The overall prognosis is generally poor due to rapid progression and poor response to therapy. Tumor size may be a prognostic factor.
History and etymology
It was first described by Mathé et al. in 1970.