Last revised by Sonam Vadera on 30 Oct 2022

Histoplasmoma is the name for a specific kind of nodule secondary to granulomatous reaction to histoplasmosis infection. It is often described as having a pathognomonic target lesion appearance, describing a well-defined nodule with a central core of calcification 5.

Histoplasmomas can appear in the lungs or central nervous system. Although classically conceived as a solitary lesion, there are reports of multiple histoplasmomas in a single patient 1. Histoplasmomas vary in size and may grow over time, and can even exceed the technical definition of a pulmonary nodule's size (i.e. >3 cm) 3.

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