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Citation:
Moore C, Vadera S, Bell D, et al. Histoplasmoma. Reference article, Radiopaedia.org (Accessed on 14 Jan 2025) https://doi.org/10.53347/rID-73768
Histoplasmoma is the name for a specific kind of nodule secondary to granulomatous reaction to histoplasmosis infection. It is often described as having a pathognomonic target lesion appearance, describing a well-defined nodule with a central core of calcification 5.
Histoplasmomas can appear in the lungs or central nervous system. Although classically conceived as a solitary lesion, there are reports of multiple histoplasmomas in a single patient 1. Histoplasmomas vary in size and may grow over time, and can even exceed the technical definition of a pulmonary nodule's size (i.e. >3 cm) 3.
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1. Rachel Beekman, Jessica M. Hu, Steven I. Aronin, Maricar F. Malinis. Diagnosing Ring-Enhancing Lesions in the Brain of a Patient With AIDS Without Brain Biopsy: A Case of Central Nervous System Histoplasmoma:. (2017) The Neurohospitalist. 8 (2): 86-91. doi:10.1177/1941874417725969 - Pubmed
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2. Andrade AI, Donato M, Previgliano C, Hardjasudarma M. Histoplasmosis brain abscesses in an immunocompetent adult. A case report and literature review. (2014) The neuroradiology journal. 27 (3): 334-8. doi:10.15274/NRJ-2014-10038 - Pubmed
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3. Richmond BW, Worrell JA, Bastarache JA, Gervich DH, Slattery WR, Loyd JE. Histoplasmomas of uncommon size. (2013) Chest. 143 (6): 1795-1798. doi:10.1378/chest.12-2071 - Pubmed
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4. Paulo Marcelo Pontes Gomes de Matos, Aloisio Felipe-Silva, José Pinhata Otoch. Pulmonary histoplasmoma: a disguised malady. (2018) Autopsy and Case Reports. doi:10.4322/acr.2018.065 - Pubmed
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5. de Matos P, Felipe-Silva A, Otoch J. Pulmonary Histoplasmoma: A Disguised Malady. Autops Case Rep. 2018;8(4):e2018065. doi:10.4322/acr.2018.065 - Pubmed
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