HNF 1 alpha mutated hepatic adenoma
Citation, DOI & article data
HNF 1 alpha mutated hepatic adenomas are a genetic and pathologic subtype of hepatic adenoma. Their appearance and prognosis are different from other subtypes.
They are the second most common (30-35%) hepatic adenoma after the inflammatory subtype. They occur only in female patients, most with a history of oral contraceptive (OCP) use.
May develop right upper quadrant pain from intratumoral hemorrhage.
This subtype of adenoma is multiple in ~50%.
- T1: isointense or hyperintense relative to liver
T1 C+ (Gd)
- moderate arterial phase enhancement (less than inflammatory subtype)
- less likely to have persistent enhancement on portal venous and delayed phases, cf. inflammatory subtype
- IP/OP: signal drop out on the out-of-phase sequence
- T2: isointense to mildly hyperintense
Treatment and prognosis
If a hepatic adenoma is suspected on imaging, patients usually stop their oral contraceptive and the lesion regresses.
If the lesion does not regress, then one treatment pathway suggests:
- ≥5 cm: resection (hepatic adenomas larger than 5 cm are at increased risk of hemorrhage)
- <5 cm: biopsy
Tissue diagnosis then confirms or changes the adenoma subtype. If HNF 1 alpha mutated subtype is confirmed, management consists of:
- clinical and imaging follow up of any remaining adenomas until menopause
- resection or thermal ablation of enlarging adenomas that grow >5 cm
- genetic counseling if there is hepatic adenomatosis, familial history of hepatic adenoma, or MODY3 (mature onset diabetes of the young, type 3)
There is also a very small risk that a hepatic adenoma may develop into a hepatocellular carcinoma (HCC).
- other types of hepatic adenoma
hepatocellular carcinoma (HCC)
- washout tends to leave the lesion hypointense compared to the rest of liver
- different demographics
- may be difficult to distinguish if well differentiated 7
- focal nodular hyperplasia (FNH)
- liver metastases (hypervascular)
- for other differential considerations, see the main article: hepatic adenoma
- 1. Katabathina VS, Menias CO, Shanbhogue AK et-al. Genetics and imaging of hepatocellular adenomas: 2011 update. Radiographics. 2011;31 (6): 1529-43. doi:10.1148/rg.316115527 - Pubmed citation
- 2. Bioulac-Sage P, Laumonier H, Couchy G et-al. Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology. 2009;50 (2): 481-9. doi:10.1002/hep.22995 - Pubmed citation