The Holman-Miller sign (also called the antral sign) is seen in juvenile nasopharyngeal angiofibroma; it refers to the anterior bowing of the posterior wall of the maxillary antrum as seen on a lateral skull radiograph or cross-sectional imaging 1,2.
This is a non-specific sign that can be produced by any slowly-growing mass, whereas erosion of the pterygoid lamina maybe pathognomonic for juvenile nasopharyngeal angiofibroma 3.
History and etymology
Colin B Holman and W Eugene Miller, American radiologists, described their eponymous sign on plain radiographs in a paper in 1965 4.
- 1. . Smart Study Series: ENT and Head & Neck Surgery. Elsevier India. ISBN:8131217078. Read it at Google Books - Find it at Amazon
- 2. . Otolaryngology Cases. Thieme. (2010) ISBN:1604063211. Read it at Google Books - Find it at Amazon
- 3. Haaga JR, Boll D. CT and MRI of the whole body. Mosby. (2009) ISBN:0323053750. Read it at Google Books - Find it at Amazon
- 4. Holman CB and Miller WE. Juvenile nasopharyngeal fibroma: roentgenologic characteristics. American Journal of Roentgenol. Rad. Therapy & Nuclear Med 1965;94:292-298.
- 5. Earnest F. Colin B. Holman. American Journal of Roentgenology. 2009;193: 1461-1462.