Holman-Miller sign (maxillary sinus)

The Holman-Miller sign (also called the antral sign) is seen in juvenile nasopharyngeal angiofibroma; it refers to the anterior bowing of the posterior wall of the maxillary antrum as seen on a lateral skull radiograph or cross-sectional imaging 1,2.

This is a non-specific sign that can be produced by any slowly-growing mass, whereas erosion of the pterygoid lamina maybe pathognomonic for juvenile nasopharyngeal angiofibroma 3.

History and etymology

Colin B Holman and W Eugene Miller, American radiologists, described their eponymous sign on plain radiographs in a paper in 1965 4.

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Article information

rID: 21804
System: Head & Neck
Section: Signs
Synonyms or Alternate Spellings:
  • Antral sign (maxillary sinus)
  • Antral sign of juvenile nasopharyngeal angiofibroma
  • Holman Miller sign
  • Holman Miller sign of juvenile nasopharyngeal angiofibroma

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