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Human epididymis protein 4

Human epididymis protein 4 (HE4) is an emerging serum biomarker in the assessment of epithelial ovarian tumors. HE4 is a member of the whey associated protein (WAP) gene cluster and has uncertain biological function 1.

Early results indicate that HE4 has higher sensitivity and specificity than CA-125 in distinguishing malignant from a benign ovarian disease in premenopausal women 2. HE4 has a high predictive value in ruling out invasive cancers in postmenopausal women with normal CA-125 2.

Elevated serum HE4 levels have been associated with a more aggressive epithelial ovarian carcinoma phenotype 3


Article information

rID: 43548
System: Gynaecology
Section: Pathology
Synonyms or Alternate Spellings:
  • Human epididymis protein-4
  • Human epididymis protein 4 (HE4)
  • HE4
  • Human epididymal protein 4

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