Human epididymis protein 4
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At the time the article was created Cara Odenthal had no recorded disclosures.View Cara Odenthal's current disclosures
At the time the article was last revised Bahman Rasuli had no recorded disclosures.View Bahman Rasuli's current disclosures
Human epididymis protein 4 (HE4) is an emerging serum biomarker in the assessment of epithelial ovarian tumors. HE4 is a member of the whey associated protein (WAP) gene cluster and has uncertain biological function 1.
Early results indicate that HE4 has higher sensitivity and specificity than CA-125 in distinguishing malignant from benign ovarian disease in premenopausal women 2. HE4 has a high predictive value in ruling out invasive cancers in postmenopausal women with normal CA-125 2.
Elevated serum HE4 levels have been associated with a more aggressive epithelial ovarian carcinoma phenotype 3.
- 1. Bandiera E, Romani C, Specchia C et-al. Serum human epididymis protein 4 and risk for ovarian malignancy algorithm as new diagnostic and prognostic tools for epithelial ovarian cancer management. Cancer Epidemiol. Biomarkers Prev. 2011;20 (12): 2496-506. doi:10.1158/1055-9965.EPI-11-0635 - Free text at pubmed - Pubmed citation
- 2. Holcomb K, Vucetic Z, Miller MC et-al. Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women. Am. J. Obstet. Gynecol. 2011;205 (4): 358.e1-6. doi:10.1016/j.ajog.2011.05.017 - Pubmed citation
- 3. Bignotti E, Ragnoli M, Zanotti L et-al. Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients. Br. J. Cancer. 2011;104 (9): 1418-25. doi:10.1038/bjc.2011.109 - Free text at pubmed - Pubmed citation