Human metapneumovirus pulmonary infection

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Human metapneumovirus (hMPV) pulmonary infection is a recently detected condition is reported to cause mild to severe respiratory tract infection particularly in children, immunocompromised patients, and the elderly 6.

Pathology

Human metapneumovirus (HMPV), is an RNA virus and first described in 2001,. It is a common pathogen and can acute viral respiratory tract infections in all age groups.

Seropositivity for IgG against HMPV has been detected in up to 100% of persons 20 and >65 years of age, and reinfection can be common

Radiographic features

Chest x-ray

Non specific and may a variable pattern but in children according to one study 2

  • parahilar / peri-bronchovascular opacities were the most commonly observed abnormality (87% of children with HMPV).
  • lungs may also hyperinflated
  • atelectasis (40%) and consolidation (18%) have been less frequently described. 
CT 

Non specific with ground-glass opacity have been most commonly reported finding and with nodular consolidation described in a lesser number of patients 3

Involvement can often be bilateral.

  • -<p><strong>Human metapneumovirus (hMPV) pulmonary infection </strong>is a recently detected condition is reported to cause mild to severe respiratory tract infection.</p><h4>Pathology</h4><p>Human metapneumovirus (HMPV), first described in 2001, is a common pathogen and can acute respiratory tract infections in all age groups.</p><p>Seropositivity for IgG against HMPV has been detected in up to 100% of persons 20 and &gt;65 years of age, and reinfection can be common</p><h4>Radiographic features</h4><h5>Chest x-ray</h5><p>Non specific and may a variable pattern but in <strong>children</strong> according to one study <sup>2</sup></p><ul>
  • -<li>parahilar opacities were the most commonly observed abnormality (87% of children with HMPV).</li>
  • +<p><strong>Human metapneumovirus (hMPV) pulmonary infection </strong>is a recently detected condition is reported to cause mild to severe respiratory tract infection particularly in children, immunocompromised patients, and the elderly <sup>6</sup>.</p><h4>Pathology</h4><p><a title="Human metapneumovirus" href="/articles/human-metapneumovirus">Human metapneumovirus</a> (HMPV), is an RNA virus and first described in 2001. It is a common pathogen and can acute <a title="viral respiratory tract infections" href="/articles/viral-respiratory-tract-infections">viral respiratory tract infections</a> in all age groups.</p><p>Seropositivity for IgG against HMPV has been detected in up to 100% of persons 20 and &gt;65 years of age, and reinfection can be common</p><h4>Radiographic features</h4><h5>Chest x-ray</h5><p>Non specific and may a variable pattern but in <strong>children</strong> according to one study <sup>2</sup></p><ul>
  • +<li>parahilar / peri-bronchovascular opacities were the most commonly observed abnormality (87% of children with HMPV).</li>
  • -</ul>
  • +</ul><h5>CT </h5><p>Non specific with ground-glass opacity have been most commonly reported finding and with nodular consolidation described in a lesser number of patients <sup>3</sup>. </p><p>Involvement can often be bilateral.</p>

References changed:

  • 1. Koo H, Lee H, Choi S, Sung H, Kim H, Do K. Clinical and Radiologic Characteristics of Human Metapneumovirus Infections in Adults, South Korea. Emerg Infect Dis. 2019;25(1):15-24. <a href="https://doi.org/10.3201/eid2501.181131">doi:10.3201/eid2501.181131</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30560776">Pubmed</a>
  • 2. Hilmes M, Daniel Dunnavant F, Singh S et al. Chest Radiographic Features of Human Metapneumovirus Infection in Pediatric Patients. Pediatr Radiol. 2017;47(13):1745-50. <a href="https://doi.org/10.1007/s00247-017-3943-5">doi:10.1007/s00247-017-3943-5</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/28831577">Pubmed</a>
  • 3. Keske Ş, Gümüş T, Köymen T, Sandıkçı S, Tabak L, Ergönül Ö. Human Metapneumovirus Infection: Diagnostic Impact of Radiologic Imaging. J Med Virol. 2019;91(6):958-62. <a href="https://doi.org/10.1002/jmv.25402">doi:10.1002/jmv.25402</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30659630">Pubmed</a>
  • 4. Franquet T. Imaging of Pulmonary Viral Pneumonia. Radiology. 2011;260(1):18-39. <a href="https://doi.org/10.1148/radiol.11092149">doi:10.1148/radiol.11092149</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/21697307">Pubmed</a>
  • 5. Sumitomo K, Morizumi S, Takahashi K et al. Human Metapneumovirus-Associated Community-Acquired Pneumonia in Adults During the First Wave of COVID-19. J Rural Med. 2021;16(4):263-9. <a href="https://doi.org/10.2185/jrm.2021-035">doi:10.2185/jrm.2021-035</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/34707737">Pubmed</a>
  • 6. Shafagati N & Williams J. Human Metapneumovirus - What We Know Now. F1000Res. 2018;7:135. <a href="https://doi.org/10.12688/f1000research.12625.1">doi:10.12688/f1000research.12625.1</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29744035">Pubmed</a>
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