Hurthle cells are a type of oncocyte arising from thyroid follicular epithelial cells.
Under microscopy, Hurthle cells are larger than typical follicular cells, with abundant mitochondria.
Cancers of Hurthle cell origin can be benign adenomas or malignant carcinomas and consist of at least 75% Hurthle cells. Previously considered a subtype of follicular thyroid cancer.
Other conditions in which Hurthle cells are found include:
History and etymology
The Hurthle cell is was first described by Max Askanazy in 1898, though the cell is named after Karl Hurthle who was a German histologist who described parafollicular C cells.
- 1. Cannon J. The significance of hurthle cells in thyroid disease. (2011) The oncologist. 16 (10): 1380-7. doi:10.1634/theoncologist.2010-0253 - Pubmed
- 2. Montone, Kathleen T., Zubair W. Baloch, and Virginia A. LiVolsi. "The thyroid Hurthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review." Archives of Pathology and Laboratory Medicine 132.8 (2008): 1241-1250.