Elfeky M, St-Amant M, Di Muzio B, et al. Hyaline degeneration of a leiomyoma. Reference article, Radiopaedia.org (Accessed on 22 Jan 2025) https://doi.org/10.53347/rID-17074
It is thought to occur in up to 60% of uterine leiomyomas 3.
Pathology
As with many other types of degeneration, it happens when fibroids outgrow their blood supply 4. Hyaline degeneration involves the presence of homogeneous eosinophilic bands or plaques in the extracellular space, which represent the accumulation of proteinaceous tissue 1.
Radiographic features
MRI
Typical signal characteristics of a leiomyoma with hyaline or calcific degeneration are difficult to distinguish from non-degenerated fibroids on pelvic MRI. Areas of calcification can appear as signal voids on MRI 2.
Therefore typical characteristics include 2,3,5:
T1: isointense
T2: hypointense
T1 C+ (Gd): low enhancement in comparison to regular leiomyoma
5. Elizabeth Kagan Arleo, Peter E. Schwartz, Pei Hui, Shirley McCarthy. Review of Leiomyoma Variants. (2015) American Journal of Roentgenology. 205 (4): 912-21. doi:10.2214/AJR.14.13946 - Pubmed
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