Hyaline degeneration is the most common form of degeneration that can occur in a uterine leiomyoma.
It is thought to occur in up to 60% of uterine leiomyomas 3.
As with many other types of degeneration, it happens when fibroids outgrow their blood supply 4. Hyaline degeneration involves the presence of homogeneous eosinophilic bands or plaques in the extracellular space, which represent the accumulation of proteinaceous tissue 1.
Typical signal characteristics of a leiomyoma with hyaline or calcific degeneration are difficult to distinguish from non-degenerated fibroids on pelvic MRI. Areas of calcification can appear as signal voids on MRI 2.
Therefore typical characteristics include 2,3,5:
- T1: isointense
- T2: hypointense
- T1 C+ (Gd): low enhancement in comparison to regular leiomyoma
- 1. Murase E, Siegelman ES, Outwater EK et-al. Uterine leiomyomas: histopathologic features, MR imaging findings, differential diagnosis, and treatment. Radiographics. 19 (5): 1179-97. Radiographics (full text) - Pubmed citation
- 2. Wilde S, Scott-barrett S. Radiological appearances of uterine fibroids. Indian J Radiol Imaging. 19 (3): 222-31. doi:10.4103/0971-3026.54887 - Free text at pubmed - Pubmed citation
- 3. Ueda H, Togashi K, Konishi I et-al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics. 1999;19 Spec No : S131-45. - Pubmed citation
- 4. Hamm B, Baert AL, Beinder E( et-al. MRI and CT of the Female Pelvis. Springer Verlag. (2010) ISBN:3642060897. Read it at Google Books - Find it at Amazon
- 5. Elizabeth Kagan Arleo, Peter E. Schwartz, Pei Hui, Shirley McCarthy. Review of Leiomyoma Variants. (2015) American Journal of Roentgenology. 205 (4): 912-21. doi:10.2214/AJR.14.13946 - Pubmed