Hydrolyzed reduced technetium-99m

Last revised by Francesco Sciacca on 14 Mar 2020

Citation, DOI, disclosures and article data

Citation:

Sciacca F, Bell D, Hydrolyzed reduced technetium-99m. Reference article, Radiopaedia.org (Accessed on 25 Apr 2024) https://doi.org/10.53347/rID-74936

DOI:

https://doi.org/10.53347/rID-74936

Permalink:

https://radiopaedia.org/articles/74936

rID:

74936

Article created:

10 Mar 2020, Francesco Sciacca ◉

Disclosures:

At the time the article was created Francesco Sciacca had no recorded disclosures.

View Francesco Sciacca's current disclosures

Last revised:

14 Mar 2020, Francesco Sciacca ◉

Disclosures:

At the time the article was last revised Francesco Sciacca had no recorded disclosures.

View Francesco Sciacca's current disclosures

Revisions:

9 times, by 2 contributors - see full revision history and disclosures

Sections:

Imaging Technology

Synonyms:

Reduced hydrolyzed Tc-99m

Hydrolyzed reduced technetium-99m (HR-Tc-99m) is a secondary product of the radiolabeling process. It is the chemical species of reduced technetium-99m; oxidation states: +5 and +4. It represents one of the possible impurities present in the technetium agents. It does not bind to the carrier molecule, for example MDP, HMPAO, etc.

The hydrolyzed technetium tends to complex with tin and oxygen, forming insoluble colloidal contaminant compounds (Tc-Sn and TcO₂), reducing the radiochemical purity of the radiopharmaceutical.

Quality controls

To know the percentage of HR-Tc-99m present in the radiopharmaceutical and therefore its radiochemical purity, it is possible to use chromatographic techniques: HPLC (high performance liquid chromatography), ITLC (istant thin layer chromatography), etc.