Hyperacute lung transplant rejection
Citation, DOI, disclosures and article data
At the time the article was created Craig Hacking had no recorded disclosures.View Craig Hacking's current disclosures
At the time the article was last revised Henry Knipe had no recorded disclosures.View Henry Knipe's current disclosures
Hyperacute lung transplant rejection is a rare, rapid and often fatal form of early post lung transplant complications.
Hyperacute rejection occurs in the first few hours after reperfusion of the allograft lungs.
Following recommencement of blood flow into the allograft, recipient preformed antibodies to donor lung antigens are released and rapidly cause pulmonary edema. Intraoperative pulmonary edema has been observed 2.
Plain radiograph and CT
Treatment and prognosis
Plasmapheresis has been trialled. Mortality is very high.