Hyperosmolar hyperglycaemic state

Hyperosmolar hyperglycaemic state (HHS) (previously known as hyperosmolar non-ketotic coma (HONK)) is a serious metabolic derangement that can occur in patients with diabetes mellitus, predominantly those with type 2. While there are no distinct imaging features, it is useful for a radiologist to be familiar with this condition.

It usually occurs in type 2 diabetics who have some concomitant illness that leads to reduced fluid intake.

High blood glucose levels lead to severe dehydration, increases in osmolarity (relative concentration of solute) and, in turn, carries a high risk of complications, coma and death.

HHS is thought to have been first described by von Frerichs and Dreschfeld in the 1880s 1.

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Article information

rID: 38710
Synonyms or Alternate Spellings:
  • Non-ketotic hyperglycaemia
  • Hyperosmolar non-ketotic coma (HONK)
  • HONK
  • Hyperosmolar hyperglycaemic state (HHS)
  • Nonketotic hyperglycaemia

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