Hypervitaminosis A results from an excess of vitamin A. It usually manifests in children, and one recognised cause is administration from 13-cis retinoic acid for treatment of cancers such as neuroblastoma.
Manifestations can differ depending on whether it is an acute or chronic excess of vitamin A.
- pruritus, dry skin, dry lips
- soft tissue nodules
- diffuse symmetric periostitis (scintigraphy may allow earlier detection 2)
- may cause premature fusion of ossification centers
- separation of cranial sutures
- tendinous/ligamentous calcifications
- infantile cortical hyperostosis (Caffey's disease): for skeletal manifestations
- 1. Miller JH, Hayon II. Bone scintigraphy in hypervitaminosis A. AJR Am J Roentgenol. 1985;144 (4): 767-8. AJR Am J Roentgenol (citation) - Pubmed citation
- 2. Pennes DR, Ellis CN, Madison KC et-al. Early skeletal hyperostoses secondary to 13-cis-retinoic acid. AJR Am J Roentgenol. 1984;142 (5): 979-83. AJR Am J Roentgenol (abstract) - Pubmed citation