Hypervitaminosis A
Dr Henry Knipe ◉ et al.
Hypervitaminosis A results from an excess of vitamin A. It usually manifests in children, and one recognised cause is administration from 13-cis retinoic acid for treatment of cancers such as neuroblastoma.
Pathology
Manifestations can differ depending on whether it is an acute or chronic excess of vitamin A.
Acute
Chronic
- pruritus, dry skin, dry lips
- soft tissue nodules
- diffuse symmetric periostitis (scintigraphy may allow earlier detection 2)
- may cause premature fusion of ossification centers
- separation of cranial sutures
- hepatosplenomegaly
- tendinous/ligamentous calcifications
Differential diagnosis
- infantile cortical hyperostosis (Caffey's disease): for skeletal manifestations
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