Hypervitaminosis A
Citation, DOI, disclosures and article data
Citation:
Knipe H, Bell D, Hacking C, et al. Hypervitaminosis A. Reference article, Radiopaedia.org (Accessed on 21 Mar 2025) https://doi.org/10.53347/rID-31018
rID:
31018
Article created:
Disclosures:
At the time the article was created Henry Knipe had no recorded disclosures.
View Henry Knipe's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Radiopaedia Events Pty Ltd, Speaker fees (past)
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Revisions:
7 times, by
5 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- Vitamin A excess
- Excess vitamin A
- Vitamin A toxicity
- Vitamin A overdose
Hypervitaminosis A results from an excess of vitamin A. It usually manifests in children, and one recognised cause is administration from 13-cis retinoic acid for treatment of cancers such as neuroblastoma.
Clinical presentation
Manifestations can differ depending on whether it is an acute or chronic excess of vitamin A.
Acute
Chronic
- pruritus, dry skin, dry lips
- soft tissue nodules
- diffuse symmetric periostitis (scintigraphy may allow earlier detection 2)
- may cause premature fusion of ossification centres
- separation of cranial sutures
- hepatosplenomegaly
- tendinous/ligamentous calcifications
Differential diagnosis
- infantile cortical hyperostosis (Caffey disease): for skeletal manifestations
References
- 1. Miller J & Hayon I. Bone Scintigraphy in Hypervitaminosis A. AJR Am J Roentgenol. 1985;144(4):767-8. doi:10.2214/ajr.144.4.767 - Pubmed
- 2. Pennes D, Ellis C, Madison K, Voorhees J, Martel W. Early Skeletal Hyperostoses Secondary to 13-Cis-Retinoic Acid. AJR Am J Roentgenol. 1984;142(5):979-83. doi:10.2214/ajr.142.5.979 - Pubmed
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