Hypervitaminosis A

Last revised by Dr Henry Knipe on 07 Jun 2022

Hypervitaminosis A results from an excess of vitamin A. It usually manifests in children, and one recognized cause is administration from 13-cis retinoic acid for treatment of cancers such as neuroblastoma.

Clinical presentation

Manifestations can differ depending on whether it is an acute or chronic excess of vitamin A. 

Acute
Chronic
  • pruritus, dry skin, dry lips
  • soft tissue nodules
  • diffuse symmetric periostitis (scintigraphy may allow earlier detection 2)
  • may cause premature fusion of ossification centers
  • separation of cranial sutures
  • hepatosplenomegaly
  • tendinous/ligamentous calcifications

Differential diagnosis

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