Hypoparathyroidism

Dr Mostafa El-Feky and Dr Henry Knipe et al.

Hypoparathyroidism results from reduced secretion of parathyroid hormone by the parathyroid glands. It results in hypocalcemia.

Hypoparathyroidism has an estimated prevalance 37 per 100,000 person-years and incidence of 0.8 per 100 000 person-years. It carries no increased risk of mortality. The majority of cases are due to complications from anterior neck surgery.4

  • tetany: peripheral paresthaesia, carpopedal spasm, seizures
  • emotional lability, depression and anxiety, psychosis
  • short stature

There are a number of causes of hypoparathyroidism 1:

  • iatrogenic, e.g. post parathyroidectomy or thyroidectomy
  • congenital absence of the parathyroid glands, which may be syndromic in thymic aplasia, or 22q11.2 deletion syndrome (a.k.a. DiGeorge syndrome)
  • familial, e.g. autoimmune polyendocrine syndrome type 1
  • idiopathic (probably autoimmune-mediated destruction)
  • parathyroid hormone (PTH) level: low
  • serum phosphate level: high
  • serum calcium level: low  

Article information

rID: 39959
System: Head & Neck
Synonyms or Alternate Spellings:
  • Low parathyroid levels

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Cases and figures

  • Case 1: skull vault thickening and falcine calcification
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