Last revised by Dr Daniel J Bell on 21 Oct 2019

Hypotelorism refers to an abnormal decrease in distance between any two organs although some authors use the term synonymously with orbital hypotelorism meaning an abnormal decrease in the distance between the two eyes (the eyes appear too close together). The article mainly focuses on the latter.

The majority of cases of orbital hypotelorism are associated with other anomalies. Such recognized associations include:

Can be assessed by measuring the interocular distance/diameter (IOD) and the binocular diameter (BOD) both of which are typically reduced with hypotelorism. These are best measured in the axial plane.

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Cases and figures

  • Case 1: with trigonocephaly
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  • Case 2: with alobar holoprosencephaly
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