I-123 ioflupane

I123 ioflupane is a radiopharmaceutical for the diagnosis of Parkinson disease and its differential diagnoses.

Characteristics

  • iodine-123 is a cyclotron product
  • physical half-life is 13.22 hours
  • predominant energy of its gamma spectrum is 159 keV

Ioflupane is the international nonproprietary name of a phenyltropane compound (FPCIT), a cocaine analogue. Ioflupane has a high affinity for presynaptic dopamine transporters which are abundant in the striatal region.

I-123 ioflupane is available worldwide and marketed under the trade name DaTSCAN TM.

Uses, doses and timing

  • as a cyclotron product, the solution is supplied ready to inject
  • the dose reference activity of I-123 ioflupane is 185 MBq
  • administration is intravenous
  • thyroid blocking with 120 mg potassium iodide 2 hours before and 24 hours after the injection is recommended
  • SPECT scanning typically occurs 3-6 hours after injection
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Article information

rID: 23245
Section: Physics
Synonyms or Alternate Spellings:
  • DaTSCAN
  • FP-CIT
  • FPCIT

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