Dr Daniel J Bell et al.

Ichthyosis is a heterogeneous set of dermatologic conditions marked out by their phenotype of diffuse dryness of the skin. Ichthyosis is usually inherited, but rarely maybe acquired.

Inherited ichthyosis (II) accounts for the majority of cases.  Ichthyosis vulgaris, the commonest form has an estimated prevalence in UK schoolchildren of 1 in 250 3.

Acquired Ichthyosis (AI) is rare and occasionally a paraneoplastic manifestation. 

  • non-Hodgkin lymphoma
  • Kaposi sarcoma
  • multiple myeloma
  • leiomyosarcoma
  • breast
  • ovarian
  • cervical
  • autoimmune
  • systemic inflammatory disease
  • endocrine/metabolic disorders
  • HIV infection
  • medication-related

Generalized scaling and dryness of the skin with flaking and itching. On visual inspection is a classic phenotype.

Inherited ichthyosis is divided into syndromic and non-syndromic forms. Mutations have now been found in more than 25 different genes 3.

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Generally symptomatic.

Article information

rID: 60025
Synonyms or Alternate Spellings:

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