Idiopathic eosinophilic esophagitis
Citation, DOI and article data
Idiopathic eosinophilic esophagitis is an inflammatory disease of the esophagus characterized by eosinophilia that can involve all the layers of the esophagus.
It is most commonly seen in males aged 20-40. It is an uncommon disease; however not rare.
Patients typically present with dysphagia or with food stuck in the esophagus. Usually, a specific food or allergen triggers the presentation, and symptoms may persist for a long time afterwards.
The exact etiology is unknown. Exposure to food or allergen triggers the activation of eosinophils within the esophageal wall and a consequent inflammatory cascade ensues.
Esophageal strictures, webs and spasm cause the presentation of food impaction.
- 'ringed' esophagus: concentric, ring-like strictures of the esophagus on a barium swallow
- these ring-like strictures may co-exist with longer strictures and may be associated with esophageal spasm, dysmotility and foreshortening
- non-specific esophageal submucosal edema
Treatment and prognosis
It is self-limiting in some cases but responds well to oral glucocorticoid therapy. It may lead to growth retardation in some children.
- 1. Zimmerman SL, Levine MS, Rubesin SE et-al. Idiopathic eosinophilic esophagitis in adults: the ringed esophagus. Radiology. 2005;236 (1): 159-65. doi:10.1148/radiol.2361041100 - Pubmed citation
- 2. Atkins D, Kramer R, Capocelli K, Lovell M, Furuta GT. Eosinophilic esophagitis: the newest esophageal inflammatory disease. (2009) Nature reviews. Gastroenterology & hepatology. 6 (5): 267-78. doi:10.1038/nrgastro.2009.45 - Pubmed
- 3. Raheem M, Leach ST, Day AS, Lemberg DA. The pathophysiology of eosinophilic esophagitis. (2014) Frontiers in pediatrics. 2: 41. doi:10.3389/fped.2014.00041 - Pubmed
- 4. Musil M. Serological differences between some isolates of bean yellow mosaic virus. (1975) Acta virologica. 19 (6): 473-80. Pubmed