IgG4-related sclerosing disease

IgG4 related sclerosing disease is a systemic disease that is characterised by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs.

Clinical presentation

Clinical manifestations are apparent in the pancreas, biliary tree, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prostate, in which tissue fibrosis with obliterative phlebitis is pathologically induced. These organ systems may be either synchronously or sequentially involved.

IgG4 related diseases are more common in middle age or elderly males.


The disease spectrum can include:

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Article Information

rID: 17290
Section: Gamuts
Synonyms or Alternate Spellings:
  • IgG4 associated sclerosing disease
  • IgG4 sclerosing disease
  • Immunoglobulin G4 (IgG4)-related sclerosing disease

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Cases and Figures

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    Case 1: IgG4-related hypophysitis
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