Immature ovarian teratoma

Immature ovarian teratomas are uncommon ovarian germ cell tumors. They differ from mature ovarian teratomas (dermoid cysts) both histologically by the presence of immature tissue, and clinically by their more malignant behavior.

Epidemiology

They are considerably less common than mature ovarian teratomas, representing less than 1% of ovarian teratomas ¹. They also affect a younger age group, occurring most often in the first two decades of life (accounting for 10-20% malignant ovarian tumors in this age group).

Clinical presentation

Presentation may be with a palpable pelvic mass or less commonly with abdominal pain ².

Pathology

An immature cystic teratoma is characterized by the presence of immature or embryonic tissue, as well as the mature tissue elements seen in a mature teratoma. The proportion of immature neuroepithelium present correlates with the tumor grade (and hence prognosis) ⁵.

Macroscopically, immature teratomas are large, encapsulated masses which have a prominent solid component. As well as this, they may feature many of the components seen in a mature teratoma, such as hair, cartilage, bone and calcification.

Associations

• ipsilateral mature cystic teratoma: ~25% ¹
• contralateral immature teratoma: ~10% ¹

Markers

• usually, does not produce beta-HCG
• serum AFP elevation in 50% ²

Radiographic features

The imaging appearance is typical of a large, heterogeneous mass with a prominent solid component. However, the spectrum of appearances ranges from a predominantly cystic to a mostly solid mass. Immature teratomas tend to be larger than mature cystic teratomas at initial presentation.

Extension through the tumor capsule may be present.

Immature teratoma may metastasize to the peritoneum, liver or lung. Metastasis to the brain has also been reported ⁷.

Ultrasound

Ultrasound appearance can be as a complex adnexal mass although is non-specific. Calcifications may be present.

CT/MRI

The presence of a prominent solid component containing calcifications and small foci of fat is suggestive. Cystic components may contain serous, mucinous, or fatty sebaceous material. Hemorrhage may be present.

Treatment and prognosis

Treatment is generally with oophorectomy, and if distant metastases are present postoperative chemotherapy. Chemotherapeutic retro conversion is a phenomenon where the teratoma or its metastasis post radiotherapy become more histologically mature than the primary lesion.

Prognosis depends on the stage.

Complications

• peritoneal rupture
• torsion

Differential diagnosis

On imaging consider:

• mature ovarian teratoma
  • tend to be smaller with more cystic change
  • no evidence of metastases

See also

• ovarian tumors