Immune mediated necrotizing myopathy

Last revised by Dr Daniel J Bell on 10 Jul 2022

Immune mediated necrotizing myopathy (IMNM) is classified as a form or myopathy and sometimes a form of myositis.

It is clinically characterized by a subacute muscle weakness (primarily proximal limbs and trunk) in combination with elevated levels of serum creatine kinase (CK) levels.

Immune mediated necrotizing myopathy may result in severe and extensive lower limb muscle edema, fatty replacement and atrophy.

The pelvic muscles and adductors are thought to be more involved in immune mediated necrotizing myopathy compared to conditions such as polymyositis or dermatomyositis 1.


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