Immunodeficiency-associated CNS lymphomas

Immunodeficiency-associated CNS lymphomas are recognized in the current (2016) WHO classification of CNS tumors as a specific subtype of primary CNS lymphoma. A number of further specific subtypes are recognized, including:


In most instances, and unlike sporadic primary CNS lymphomas, these tumors are associated with prior EBV infection 1. They express EBER1, EBER2, LMP1 and EBNA1-6 1.

Predisposing conditions

Essentially any cause of immunosuppression increases the risk of developing primary CNS lymphoma, including 1

Radiographic features

Although generally, the features of immunodeficiency-associated CNS lymphomas is similar to that of sporadic primary CNS lymphomas, in the setting of immunodeficiency tumors are more likely to be: 

  • heterogeneous peripheral enhancement with central non-enhancement (due to necrosis). This is in contrast to solid homogeneous enhancement in immunocompetent lymphoma
  • multifocal
  • surrounded by a greater degree vasogenic edema

Article information

rID: 53116
Synonyms or Alternate Spellings:

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Figure 1: gross pathology
    Drag here to reorder.
  • Case 1
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.