Infarct core

A.Prof Frank Gaillard et al.

The infarct core denotes the part of an acute ischaemic stroke which has already infarcted, or is irrevocably destined to infarct regardless of reperfusion. It is also referred as established infarct and is in distinction from the penumbra which remains potentially salvageable. 

CT perfusion

On CT perfusion the infarct core is defined as the area of the brain with 1-2

  1. increased mean transit time (MTT)
  2. markedly decreased relative cerebral blood flow (CBF): <30% normal
  3. decreased cerebral blood volume (CBV): <40% normal

In contrast, the ischaemic penumbra will have only moderately decreases CBF and normal or even increased CBV due to autoregulation. 


On MRI, the infarct core correlates closely with restricted diffusion on diffusion-weighted imaging 1

Stroke and intracranial haemorrhage
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rID: 24523
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Cases and figures

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    Case 1: increased MTT
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    Case 1: markedly decreased CBF
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    Case 1: decreased CBV
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