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Inferior vena caval thrombosis

Inferior vena caval (IVC) thrombosis is an essential diagnosis while evaluating any neoplastic lesion, or portal hypertension. It is also important to differentiate bland thrombus from tumor thrombus.

Patient can present with many features which include

Inferior vena cava thrombus can be classified under two broad headings:

  1. bland thrombus
  2. tumor thrombus

Bland thrombus can be an isolated thrombus or commonly arising from deep vein thrombosis of the lower extremities.

  • hypercoagulable states
  • venous stasis
  • compression by neoplastic lesions, lymph nodes, retroperitoneal masses/fibrosis or hemorrhage
  • foreign bodies: vena cava filter, catheters
  • extension from benign tumors: angiomyolipoma, inferior vena cava leiomyoma, adrenal pheochromocytoma
  • traumatic liver injury: very rare 4

While any neoplastic lesion can cause inferior vena cava thrombosis, renal cell carcinoma is the most common malignancy to extend into the inferior vena cava 1. Other tumors that have a tendency for inferior vena cava thrombosis are hepatocellular carcinoma, adrenocortical cancer and Wilms tumor, primary leiomyoma or leiomyosarcoma of the inferior vena cava.

It is important to characterize the thrombus from renal cell carcinoma for surgical management.

According to TNM staging of renal cell carcinoma, tumor spread into the infradiaphragmatic inferior vena cava is T3c stage, while extension into the supradiaphragmatic inferior vena cava is T4b stage. Also, subclassification into infrahepatic, hepatic and suprahepatic extension can further help the surgeon.

On all imaging, they appear as persistent filling-defects within the inferior vena cava. Chronic thrombosis can lead to pericaval and periaortic collateral formation 1.

  • a bland thrombus results from external compression of the inferior vena cava by a neoplastic lesion (i.e. no direct invasion), so the inferior vena cava is usually narrowed at the site of thrombosis; in contrast, tumor thrombus expands the inferior vena cava
  • tumor thrombus will often show continuity with primary tumor
  • in arterial phase, neovascularity may be appreciated in tumor thrombus

Conditions that may mimic thrombus include:

  • pseudothrombosis caused by laminar flow of enhanced blood from renal veins streaming parallel to column of unopacified blood returning from lower body; delayed images will show resolution of filling defect
  • pseudolipoma (paracaval lipoma) is the partial volume artifact due to pericaval fat above caudate lobe, seen commonly in patients with chronic liver disease; coronal reformats usually clear the doubt 2

Article information

rID: 16688
Synonyms or Alternate Spellings:
  • IVC thrombus
  • Inferior venacava thrombosis
  • Inferior venacava thrombus
  • IVC thrombosis
  • Inferior vena cava thrombosis
  • Thrombosis of the inferior vena cava

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Cases and figures

  • Case 1: tumor thrombus CEUS
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  • Case 1: tumor thrombus power Doppler
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  • Case 2
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  •  Case 3
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  • Case 4
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  • Case 5
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  • Case 6: left sided IVC filter with IVC thrombosis
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  • Case 7
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  • Case 8: below filter IVC thrombosis
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  • Chronic IVC thrombosis with extensive collaterals
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