Infiltrating syringomatous adenoma of the nipple
Infiltrating syringomatous adenoma of the nipple is a relatively rare, benign dermal neoplasm in the areola and nipple.
Syringomatous adenomas of the nipple usually present as unilateral 1 to 3 cm firm lesion in the subareolar or nipple region of the breast. Tenderness, itchiness, crusting, ulceration, and nipple discharge or nipple inversion may be present. Average age at the time of presentation is 40 years of age.
Dermal nodule in the subareolar location.
Epidermal acanthosis and pseudoepitheliomatous hyperplasia. Dermal infiltrates of curved, ductular structures lined by flattened-to-cuboidal cells, often with proteinaceous debris and skin-type keratin seen in their lumens. Keratinous cysts are often seen 3.
Treatment and prognosis
Complete excision is curative, with local recurrences occurring in 30% of incompletely excised lesions.
It was first described by Rosen in 1983.
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- 2. Carter E, Dyess DL. Infiltrating syringomatous adenoma of the nipple: a case report and 20-year retrospective review. Breast J. 2004;10 (5): 443-7. doi:10.1111/j.1075-122X.2004.21518.x - Pubmed citation
- 3. Oo KZ, Xiao PQ. Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review. Arch. Pathol. Lab. Med. 2009;133 (9): 1487-9. Pubmed citation