Infiltrating syringomatous adenoma of the nipple

Last revised by Daniel J Bell on 24 Feb 2018

Infiltrating syringomatous adenoma of the nipple is a relatively rare, benign dermal neoplasm of the areola and nipple.

Syringomatous adenomas of the nipple usually present as unilateral 1 to 3 cm firm lesion in the subareolar or nipple region of the breast. Tenderness, itchiness, crusting, ulceration, and nipple discharge or nipple inversion may be present. Average age at the time of presentation is 40 years of age.

Dermal nodule in the subareolar location.

Epidermal acanthosis and pseudoepitheliomatous hyperplasia. Dermal infiltrates of curved, ductular structures lined by flattened-to-cuboidal cells, often with proteinaceous debris and skin-type keratin seen in their lumens. Keratinous cysts are often seen 3.

Complete excision is curative, with local recurrences occurring in 30% of incompletely excised lesions.

It was first described by Rosen in 1983.

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