Inflammatory carcinoma of the breast
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Inflammatory carcinoma of the breast, also referred to as inflammatory breast cancer, is a relatively uncommon but aggressive form of invasive breast carcinoma with a characteristic clinical presentation and unique radiographic appearances.
Inflammatory carcinomas account for 1-4% of all breast cancers, typically occurring in women between the 4th to 5th decades 1.
Clinically, inflammatory breast cancer mimics mastitis. The breast is enlarged (often of relatively short onset), indurated, erythematous, warm, and may be tender and painful. The skin is thickened and edematous, classically with a "peau d’orange" appearance. There may or may not be an underlying palpable mass.
The condition may also present with flattening, erythema, crusting, blistering, or retraction of the nipple. Fixed palpable ipsilateral axillary lymph nodes, synonymous with metastatic disease, are frequently observed.
However systemic symptoms such as fever are absent which helps somewhat differentiate from mastitis. Axillary lymphadenopathy (often fixed and palpable) may be present in ~50% of cases at presentation 7.
While any subtype of primary breast carcinoma may be present, invasive ductal carcinoma tends to be the most prevalent histological type 1.
Histologically, the dermal lymphatic invasion is pathognomonic of inflammatory breast cancer but does not necessarily need to be demonstrated to make the diagnosis 10. The presence of tumorous cells in dilated lymphatics may be present in ~80% of cases 7.
Inflammatory breast cancer is a T4 tumor according to the standard TNM staging classification of breast cancer.
Mammographic findings include tumor mass and malignant microcalcifications. More specifically, inflammatory changes such as extensive skin and trabecular thickening/coarsening, and/or diffusely increased breast density are important clues that should lead the radiologist to suggest the diagnosis.
Ultrasound may be helpful to locate a hypoechoic shadowing mass, which can be obscured on mammography by diffusely increased breast density. Ultrasound may also show skin thickening (the most common and obvious finding on ultrasound), pectoral muscle invasion and axillary involvement. Ultrasound is often used to assess for areas of focal change as well as to determine a suitable site for biopsy.
According to one study, the most common MRI finding is a mass or multiple masses (73%) 8. Masses are frequently multiple, small, and confluent; mass margins, irregular; and internal enhancement pattern, heterogeneous. MRI also demonstrates evidence of skin thickening in a vast majority of cases.
Treatment and prognosis
In cases where an image-guided biopsy of the underlying intraparenchymal mass or axillary lymph nodes does not give the diagnosis, a skin biopsy may be indicated 10. Inflammatory breast cancer has a tendency to metastasize at an early stage 1.
Unlike other types of breast cancer in which surgery is the first modality of treatment, chemotherapy before surgery or radiation therapy is the current standard treatment.
- painful breast with prominent erythematous changes and fevers
- locally advanced invasive breast carcinoma
- usually, a long-term presentation that has been neglected
- lymphomatous involvement of the breast
- other causes of breast edema
- related to venous (e.g. SVC syndrome) or lymphatic obstruction (e.g. previous axillary emptying)
- 1. Günhan-bilgen I, Ustün EE, Memiş A. Inflammatory breast carcinoma: mammographic, ultrasonographic, clinical, and pathologic findings in 142 cases. Radiology. 2002;223 (3): 829-38. doi:10.1148/radiol.2233010198 - Pubmed citation
- 2. Kushwaha AC, Whitman GJ, Stelling CB et-al. Primary inflammatory carcinoma of the breast: retrospective review of mammographic findings. AJR Am J Roentgenol. 2000;174 (2): 535-8. AJR Am J Roentgenol (full text) - Pubmed citation
- 3. Dershaw DD, Moore MP, Liberman L et-al. Inflammatory breast carcinoma: mammographic findings. Radiology. 1994;190 (3): 831-4. Radiology (abstract) - Pubmed citation
- 4. Conant EF, Brennecke CM. Breast imaging, case review. Mosby Inc. (2006) ISBN:0323017460. Read it at Google Books - Find it at Amazon
- 5. Tardivon AA, Viala J, Corvellec rudelli A et-al. Mammographic patterns of inflammatory breast carcinoma: a retrospective study of 92 cases. Eur J Radiol. 1997;24 (2): 124-30. Eur J Radiol (link) - Pubmed citation
- 6. Yang WT, Le-petross HT, Macapinlac H et-al. Inflammatory breast cancer: PET/CT, MRI, mammography, and sonography findings. Breast Cancer Res. Treat. 2008;109 (3): 417-26. doi:10.1007/s10549-007-9671-z - Pubmed citation
- 7. Cardeñosa G. Clinical breast imaging, a patient focused teaching file. Lippincott Williams & Wilkins. (2006) ISBN:0781762677. Read it at Google Books - Find it at Amazon
- 8. Le-petross HT, Cristofanilli M, Carkaci S et-al. MRI features of inflammatory breast cancer. AJR Am J Roentgenol. 2011;197 (4): W769-76. doi:10.2214/AJR.10.6157 - Pubmed citation
- 9. Paredes ES. Atlas of mammography. Lippincott Williams & Wilkins. (2007) ISBN:0781764335. Read it at Google Books - Find it at Amazon
- 10. Dawood S, Merajver SD, Viens P et-al. International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann. Oncol. 2011;22 (3): 515-23. doi:10.1093/annonc/mdq345 - Free text at pubmed - Pubmed citation