Inflammatory myofibroblastic tumor
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Campos A, Niknejad M, et al. Inflammatory myofibroblastic tumor. Reference article, Radiopaedia.org (Accessed on 02 Dec 2024) https://doi.org/10.53347/rID-11033
Permalink:
rID:
11033
Article created:
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Arlene Campos had no financial relationships to ineligible companies to disclose.
View Arlene Campos's current disclosures
Revisions:
20 times, by
9 contributors -
see full revision history and disclosures
Systems:
Tags:
Synonyms:
- Inflammatory myofibroblastic tumour (IMT)
- Plasma cell granuloma
- Inflammatory myofibroblastic tumours
- Inflammatory myofibroblastic tumor
- Inflammatory myofibroblastic tumors
- Plasma cell granulomas
- Plasma-cell granuloma
- Plasma-cell granulomas
Inflammatory myofibroblastic tumors (IMT), also known as plasma cell granulomas, are rare neoplasms that have a diverse spectrum of biological behavior.
On this page:
Terminology
These tumors were previously referred to as inflammatory pseudotumors.
Epidemiology
They can occur at any age and there is no recognized gender predilection.
Pathology
Composed of spindle cells (key feature) with a variable infiltrate of inflammatory cells and fibrous tissue. They can occur at numerous sites:
-
more common 3
lung
head and neck
mesentery
gastrointestinal tract
retroperitoneum
musculoskeletal system
-
less common
liver 8
spleen 10
urogenital tract 6
Radiographic features
Radiological features of inflammatory myofibroblastic tumors suggest malignant neoplasms, whereas they are not and these lesions are underdiagnosed entities 11.
Imaging characteristics depend on the organ of involvement:
References
- 1. Kim SJ, Kim WS, Cheon JE et-al. Inflammatory myofibroblastic tumors of the abdomen as mimickers of malignancy: imaging features in nine children. AJR Am J Roentgenol. 2009;193 (5): 1419-24. doi:10.2214/AJR.09.2433 - Pubmed citation
- 2. Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: where are we now? J. Clin. Pathol. 2008;61 (4): 428-37. doi:10.1136/jcp.2007.049387 - Pubmed citation
- 3. Lai V, Wong YC, Lam WY et-al. Inflammatory myofibroblastic tumor of the nasal cavity. AJNR Am J Neuroradiol. 2007;28 (1): 135-7. AJNR Am J Neuroradiol (full text) - Pubmed citation
- 4.Van den heuvel DA, Keijsers RG, Van es HW et-al. Invasive inflammatory myofibroblastic tumor of the lung. J Thorac Oncol. 2009;4 (7): 923-6. doi:10.1097/JTO.0b013e3181a76e28 - Pubmed citation
- 5. Rasalkar D, Chu W, To K, Cheng F, Li C. Radiological Appearance of Inflammatory Myofibroblastic Tumour. Pediatr Blood Cancer. 2010;54(7):1029-31. doi:10.1002/pbc.22391 - Pubmed
- 6. Hosokawa C, Tsubakimoto M, Inoue Y, Goto T, Senju M, Yoshimura R. Radiologic Features of Inflammatory Pseudotumor of the Ureter. AJR Am J Roentgenol. 2007;188(2):W202-5. doi:10.2214/AJR.05.0578 - Pubmed
- 7. Coffin CM, Dehner LP, Meis-kindblom JM. Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: an historical review with differential diagnostic considerations. Semin Diagn Pathol. 1998;15 (2): 102-10. - Pubmed citation
- 9. Palaskar S, Koshti S, Maralingannavar M et-al. Inflammatory myofibroblastic tumor. Contemp Clin Dent. 2011;2 (4): 274-7. doi:10.4103/0976-237X.91787 - Free text at pubmed - Pubmed citation
- 10. Lee HJ, Kim JW, Hong JH, Kim GS, Shin SS, Heo SH, Lim HS, Hur YH, Seon HJ, Jeong YY. Cross-sectional Imaging of Splenic Lesions: RadioGraphics Fundamentals | Online Presentation. (2018) Radiographics : a review publication of the Radiological Society of North America, Inc. 38 (2): 435-436. doi:10.1148/rg.2018170119 - Pubmed
- 11. Cantera J, Alfaro M, Rafart D et al. Inflammatory Myofibroblastic Tumours: A Pictorial Review. Insights Imaging. 2015;6(1):85-96. doi:10.1007/s13244-014-0370-0 - Pubmed
- Venkataraman S, Semelka R, Braga L, Danet I, Woosley J. Inflammatory Myofibroblastic Tumor of the Hepatobiliary System: Report of MR Imaging Appearance in Four Patients. Radiology. 2003;227(3):758-63. doi:10.1148/radiol.2273020572 - Pubmed
Incoming Links
Articles:
- Central nervous system curriculum
- Anaplastic lymphoma kinase (ALK) gene rearrangements
- WHO classification of tumours of the breast
- Pulmonary lymphoproliferative disease
- Inflammatory myofibroblastic tumour of the spleen
- Inflammatory myofibroblastic tumours of the musculoskeletal system
- Inflammatory myofibroblastic tumours of the urogenital system
- Calcifying fibrous tumor
- Inflammatory myofibroblastic tumours of the gastrointestinal tract
- NTRK-rearranged soft tissue neoplasm
- Hepatic solitary fibrous tumour
- Splenic hamartoma
- Inflammatory myofibroblastic tumours of the mesentery
- Inflammatory myofibroblastic tumour of the lung
- Inflammatory myofibroblastic tumours of the head and neck
- Non-lymphomatous pulmonary lymphoid disorders
- WHO classification of tumours of soft tissue
- WHO classification of uterine tumours
- WHO classification of head and neck tumors
- Tolosa-Hunt syndrome
Related articles: Pathology: Hepato-Pancreato-Biliary
- liver
- depositional disorders
- infection and inflammation
- liver abscess
- hepatic hydatid infection
- cirrhosis
- hepatitis
- cholecystitis
- cholangitis
- malignancy
- liver and intrahepatic bile duct tumors
- benign epithelial tumors
- hepatocellular hyperplasia
- hepatocellular adenoma
- hepatic/biliary cysts
- benign nonepithelial tumors
- primary malignant epithelial tumors
- hepatocellular carcinoma
- hepatocellular carcinoma variants
-
cholangiocarcinoma
- intra-hepatic
- mass-forming type
- periductal infiltrating type - Klatskin tumors
- intraductal growing type
- extra-hepatic/large duct type
- intra-hepatic
- biliary cystadenocarcinoma
- combined hepatocellular and cholangiocarcinoma
- hepatoblastoma
- undifferentiated carcinoma
- primary malignant nonepithelial tumors
- hematopoietic and lymphoid tumors
- primary hepatic lymphoma
- hepatic myeloid sarcoma (hepatic chloroma)
- secondary tumors
- miscellaneous
- adrenal rest tumors
- hepatic carcinosarcoma
- hepatic fibroma
- hepatic hemangioma
- hepatic Kaposi sarcoma
- hepatic lipoma
- hepatic mesenchymal hamartoma
- hepatic myxoma
- hepatic rhabdoid tumor
- hepatic solitary fibrous tumor
- hepatic teratoma
- hepatic yolk sac tumor
- inflammatory myofibroblastic tumor (inflammatory pseudotumor)
- nodular regenerative hyperplasia
- pancreatic rest tumors
- primary hepatic carcinoid
- benign epithelial tumors
- liver and intrahepatic bile duct tumors
- metabolic
- trauma
-
vascular and perfusion disorders
- portal vein related
- hepatic artery related
- hepatic veins related
- inferior vena cava related
- other
- third inflow
- liver thrombotic angiitis
- infra diaphragmatic total anomalous pulmonary venous return (TAPVR)
- hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease)
- pancreas
-
pancreatic neoplasms
- cystic neoplasm (cystic pancreatic mass differential diagnosis)
- solid neoplasm
- non-epithelial pancreatic neoplasms
- others
- simple pancreatic cyst
-
pancreatitis (mnemonic for the causes)
- acute pancreatitis
- chronic pancreatitis
- Ascaris-induced pancreatitis
- tropical pancreatitis
- autoimmune pancreatitis
- emphysematous pancreatitis
- hypertriglyceridemia-induced pancreatitis
- hereditary pancreatitis
- pancreatitis associated with cystic fibrosis
- pancreaticopleural fistula
- segmental pancreatitis
- pancreatic atrophy
- pancreatic lipomatosis
- pancreatic trauma
- pancreatic transplant
-
pancreatic neoplasms
- gallbladder and biliary
- congenital malformations and anatomical variants
- gallstones
- gallbladder inflammation
- bile ducts inflammation
- gallbladder wall abnormalities
- other gallbladder abnormalities
- bile duct dilatation (differential)
- bile duct wall thickening (differential)
- bile ducts neoplasms
Unable to process the form. Check for errors and try again.