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Citation:
Niknejad M, Inflammatory myofibroblastic tumors of the liver. Reference article, Radiopaedia.org (Accessed on 13 Dec 2024) https://doi.org/10.53347/rID-181194
Inflammatory myofibroblastic tumors (IMTs) of the liver are extremely rare and account for just 0.7% of all hepatic lesions 1.
Refer to the article on inflammatory myofibroblastic tumors for a broad discussion.
IMTs of the liver are usually frequent in young adults and Asian people.
Several conditions have been reported and associated with hepatic IMTs such as autoimmune diseases, IgG4 disease, sclerosing cholangitis, Crohn disease and hepatic viral infections like Epstein-Barr virus 2,3,4.
Hapatic IMTs are often present due to the compression effect on adjacent structures and may cause obstructive jaundice regarding size. They can also associated with a general inflammatory response such as fever and weight loss 5.
CT
Hepatic IMTs may show homogeneous arterial enhancement with delayed washout and can mimic hepatocellular carcinomas. However, they usually show heterogeneous or peripheral arterial enhancement 6.
MRI
Hepatobiliary contrast could help differentiate HCC from hepatic IMTs. High signal intensity in the center of the lesion on the hepatobiliary phase, suggesting a benign lesion 6.
In isolated hepatic IMT,s surgical resection is the most accepted treatment 7.
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1. Tang L, Lai E, Cong W et al. Inflammatory Myofibroblastic Tumor of the Liver: A Cohort Study. World J Surg. 2010;34(2):309-13. doi:10.1007/s00268-009-0330-x - Pubmed
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2. Zen Y, Fujii T, Sato Y, Masuda S, Nakanuma Y. Pathological Classification of Hepatic Inflammatory Pseudotumor with Respect to IgG4-Related Disease. Mod Pathol. 2007;20(8):884-94. doi:10.1038/modpathol.3800836 - Pubmed
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3. Zen Y, Harada K, Sasaki M et al. IgG4-Related Sclerosing Cholangitis with and Without Hepatic Inflammatory Pseudotumor, and Sclerosing Pancreatitis-Associated Sclerosing Cholangitis: Do They Belong to a Spectrum of Sclerosing Pancreatitis? Am J Surg Pathol. 2004;28(9):1193-203. doi:10.1097/01.pas.0000136449.37936.6c - Pubmed
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4. Kim T, Han J, Kim G, Lee K, Kim H, Kim J. Pulmonary Inflammatory Pseudotumor (Inflammatory Myofibroblastic Tumor): CT Features with Pathologic Correlation. J Comput Assist Tomogr. 2005;29(5):633-9. doi:10.1097/01.rct.0000168363.60191.f8 - Pubmed
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5. Narla L, Newman B, Spottswood S, Narla S, Kolli R. Inflammatory Pseudotumor. Radiographics. 2003;23(3):719-29. doi:10.1148/rg.233025073 - Pubmed
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6. Jeong J, Sohn J, Kim T et al. Hepatic Inflammatory Pseudotumor Misinterpreted as Hepatocellular Carcinoma. Clin Mol Hepatol. 2012;18(2):239-44. doi:10.3350/cmh.2012.18.2.239 - Pubmed
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7. Tang L, Lai E, Cong W et al. Inflammatory Myofibroblastic Tumor of the Liver: A Cohort Study. World J Surg. 2010;34(2):309-13. doi:10.1007/s00268-009-0330-x - Pubmed
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