Inter twin membrane folding is an observation where the inter twin membrane in a twin pregnancy appears as being folded. It is sometimes used as a predictor for the development of twin to twin transfusion syndrome. It occurs as a result of amniotic fluid discordance.
Some reports suggest that folding of the inter-twin membrane occurs in about one-quarter of monochorionic twins where in ~43-50% half of these there can be subsequent development of twin-to-twin transfusion syndrome 1-2.
- 1. Sebire NJ, Souka A, Skentou H et-al. Early prediction of severe twin-to-twin transfusion syndrome. Hum. Reprod. 2000;15 (9): 2008-10. Hum. Reprod. (link) - Pubmed citation
- 2. Sebire NJ, D'ercole C, Carvelho M et-al. Inter-twin membrane folding in monochorionic pregnancies. Ultrasound Obstet Gynecol. 1998;11 (5): 324-7. doi:10.1046/j.1469-0705.1998.11050324.x - Pubmed citation