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Interstitial cystitis (or bladder pain syndrome) refers to an inflammatory condition affecting the bladder. It is usually defined as urinary bladder pain and irritative symptoms of more than six months' duration. It usually represents a diagnosis of exclusion. Traditionally, it has been defined as a chronic sterile inflammatory disease of the bladder of unknown etiology 3.
It tends to commonly occur in young to middle-aged women 1. The RAND Interstitial Cystitis Epidemiology Study in 2011 surveyed women in approximately 150,000 United States households and concluded that up to 6.5% have symptoms of interstitial cystitis4.
Its exact etiology is uncertain. Proposed theories of pathogenesis are wide and include chronic/subclinical infection, autoimmune phenomena, neurogenic inflammation or bladder urothelial defects.
- 1. Grover S, Srivastava A, Lee R, Tewari AK, Te AE. Role of inflammation in bladder function and interstitial cystitis. (2011) Therapeutic advances in urology. 3 (1): 19-33. doi:10.1177/1756287211398255 - Pubmed
- 2. Dasgupta J, Tincello DG. Interstitial cystitis/bladder pain syndrome: an update. (2009) Maturitas. 64 (4): 212-7. doi:10.1016/j.maturitas.2009.09.016 - Pubmed
- 3. Kelada E, Jones A. Interstitial cystitis. (2007) Archives of gynecology and obstetrics. 275 (4): 223-9. doi:10.1007/s00404-006-0247-7 - Pubmed
- 4. Berry SH, Elliott MN, Suttorp M, Bogart LM, Stoto MA, Eggers P, Nyberg L, Clemens JQ. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. (2011) The Journal of urology. 186 (2): 540-4. doi:10.1016/j.juro.2011.03.132 - Pubmed