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Intracranial choriocarcinomas are rare, accounting for only 5% of all pineal masses 2 and 10% of all intracranial germ cells tumors 1. Like other intracranial germ cell tumors, they are found both in the pineal and suprasellar region. Typically they have increased CSF and plasma b-HCG, which are helpful in establishing the diagnosis 2,3.
These tumors are highly vascular and have a propensity to hemorrhage (as do their metastases). If present blood products may be evident on MRI as signal drop-out and blooming on T2* sequences and intrinsic high T1 signal, which needs to be distinguished from calcification and fat respectively 2.
They have a propensity to metastasize hematogenously 3.
- 1. Horowitz Michael Bruce and Walter A. Hall. “Central Nervous System Germinomas: A Review.” Arch Neurol 48, no. 6 (June 1, 1991): 652-657. doi:10.1001/archneur.1991.00530180110026.
- 2. Smirniotopoulos JG, Rushing EJ, Mena H. Pineal region masses: differential diagnosis. Radiographics. 1992;12 (3): 577-96. Radiographics (abstract) - Pubmed citation
- 3. Page R, Doshi B, Sharr MM. Primary intracranial choriocarcinoma. J. Neurol. Neurosurg. Psychiatr. 1986;49 (1): 93-5. doi:10.1136/jnnp.49.1.93 - Free text at pubmed - Pubmed citation