Intracranial metastatic melanoma is the third most common brain metastasis.
For a broad discussion about the primary tumor or brain metastasis in general, please refer to the articles:
A population-based study of 169,444 cancer patients from 1973 to 2001 in Detroit revealed that ~7% of patients diagnosed with melanoma subsequently developed intracranial metastasis 2.
These patients can commonly present with headaches, seizures, mental status alterations, ataxia, nausea and vomiting, and visual disturbances. However, 10% of patients may be asymptomatic.
Melanoma metastases can be artificially divided into "melanotic" (containing greater than 10% melanotic cells on histopathology) or "amelanotic" (containing less than 10% melanotic cells). In 1995, Isiklar et al. published a study in the AJR where only melanotic metastases provided consistent and reliable MR findings (hyperintense on T1 and hypointense on T2). The MR findings of amelanotic metastases were non-specific. Unfortunately, melanotic metastases made up only 25% of the total cerebral melanoma metastases examined 7.
Intratumoral hemorrhage is a much more common feature of melanoma metastases in comparison to other brain metastases 5. Other than choriocarcinoma, metastatic melanomas are the most frequent metastases that are complicated by massive hemorrhage 6.
Typically, intracranial melanoma metastases consist of a single or multiple nodules with increased attenuation on CT. Out of a series of 101 patients with cerebral melanoma metastases, 62% were found to have multiple lesions (53% localized bilaterally), and 72% of these lesions had increased attenuation 3. Cystic degeneration and necrosis are rarely seen in these tumors 3,4.
- NECT: single to multiple nodules of increased attenuation localized to the gray/white matter junction; variable edema and frequent intratumoral hemorrhage present
- CECT: nodules typically enhance; dural-based, well-enhanced lesions are impossible to differentiate from meningiomas
The blood products alter the signal on MRI resulting in hyperintensity on T1 and hypointensity on T2 images. However, it should be noted that the melanin pigment has parallel effects on T1 and T2 relaxation times 6. Thus, the signal changes seen on MRI may be due to either melanin or blood products.
- T1: typically hyperintense secondary to hemorrhage or melanin (as above)
- T2: typically hypointense
- T1 C+: typically enhances in a peripheral rim pattern or a diffusely heterogeneous pattern
T2*: susceptibility artifacts are commonly encountered secondary to hemorrhage (they are not related to melanin content)
- reported in 42% of cases (compared to 8% of lung metastases) 12
- some metastases can solely be observable on T2*, although isolated T2* hypointensities should be interpreted cautiously, as other studies reported contradictory findings 12,13
On imaging consider:
- other hemorrhagic intracranial metastases
- other melanotic tumors
- other hemorrhages
- 1. Beresford HR. Melanoma of the nervous system. Treatment with corticosteroids and radiation. Neurology. 1969;19 (1): 59-65. Neurology (citation) - doi:10.1212/WNL.19.1.59 - Pubmed citation
- 2. Barnholtz-Sloan JS, Sloan AE, Davis FG et-al. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J. Clin. Oncol. 2004;22 (14): 2865-72. J. Clin. Oncol. (full text) - doi:10.1200/JCO.2004.12.149 - Pubmed citation
- 3. Ginaldi S, Wallace S, Shalen P et-al. Cranial computed tomography of malignant melanoma. AJR Am J Roentgenol. 1981;136 (1): 145-9. doi:10.2214/ajr.136.1.145 - Pubmed citation
- 4. Takahashi I, Sugimoto S, Nunomura M et-al. [A case of cystic metastatic intracranial amelanotic melanoma-analysis of findings in CT and MRI]. No To Shinkei. 1991;42 (11): 1031-4. Pubmed citation
- 5. Atlas SW, Grossman RI, Gomori JM et-al. MR imaging of intracranial metastatic melanoma. J Comput Assist Tomogr. 1987;11 (4): 577-82. Pubmed citation
- 6. Sealy RC. Radicals in melanin biochemistry. Meth. Enzymol. 1984;105: 479-83. Pubmed citation
- 7. Isiklar I, Leeds NE, Fuller GN et-al. Intracranial metastatic melanoma: correlation between MR imaging characteristics and melanin content. AJR Am J Roentgenol. 1995;165 (6): 1503-12. doi:10.2214/ajr.165.6.7484597 - Pubmed citation
- 8. Pennington DG, Milton GW. Cerebral metastasis from melanoma. Aust N Z J Surg. 1976;45 (4): 405-9. Pubmed citation
- 9. Satran R, McDonald JV. Malignant melanoma of the central nervous system. Neurology. 1968;18 (3): 278. Pubmed citation
- 10. Gottlieb JA, Frei E, Luce JK. An evaluation of the management of patients with cerebral metastases from malignant melanoma. Cancer. 1972;29 (3): 701-5. Pubmed citation
- 11. Fink KR, Fink JR. Imaging of brain metastases. Surg Neurol Int. 2013;4 (Suppl 4): S209-19. Free text at pubmed - Pubmed citation
- 12. P. Gaviani, M.E. Mullins, T.A. Braga, E.T. Hedley-Whyte, E.F. Halpern, P.S. Schaefer, J.W. Henson. Improved Detection of Metastatic Melanoma by T2*-Weighted Imaging. American Journal of Neuroradiology. 27 (3): 605. Pubmed
- 13. Gramsch C, Göricke SL, Behrens F, Zimmer L, Schadendorf D, Krasny A, Forsting M, Schlamann MU. Isolated cerebral susceptibility artefacts in patients with malignant melanoma: metastasis or not?. European radiology. 23 (9): 2622-7. doi:10.1007/s00330-013-2857-3 - Pubmed