Revision 6 for 'Intracranial tuberculous granuloma'

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Intracranial tuberculous granuloma

Intracranial tuberculous granulomas (also known as CNS tuberculomas) are common in endemic areas, and may occur either in isolation or along with with tuberculous meningitis.


The epidemiology of patients with tuberculomas is the same as that of other CNS manifestations of TB (see CNS tuberculosis)

Radiographic features

  • T1
    • isointense to grey-matter 1
    • may have central region of hyperintensity representing caseation
  • T2
    • isointense to grey-matter
    • may have central region of hypointensity representing gliosis and abundant monocyte infiltration 1
    • lesions are surrounded by vasogenic edema
  • T1 C+ (Gd)
    • usually appears as ring-enhancement
    • may appear as a conglomerate enhancing mass
  • MR spectroscopy
    • decrease in NAA/Cr
    • slight decrease in NAA/Cho
    • lipid-lactate peaks are usually elevated (86%) 2

Differential diagnosis

The differential of tuberculomas is essentially is the differential of ring-enhancing lesions, and includes:

Central isointensity or hypointensity compared to grey matter seen centrally on T2 is helpful, as it is not seen in most other causes 1.

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