Intracranial yolk sac tumor
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Intracranial yolk sac tumors represent 2% of nongerminomatous germ cell tumors 1.
Intracranial yolk sac tumors commonly occur in childhood or adolescence. CSF alfa fetoprotein can act as a tumor marker for yolk sac tumors.
Intracranial yolk sac tumors are usually located in the pineal gland (see pineal yolk sac tumor), suprasellar and posterior third ventricular region 1,2. Primary yolk sac tumors have also been reported in the spinal cord 3.
- T1: hypointense
- T2: hyperintense
- T1 C+ (Gd): heterogenous enhancement
Hemorrhage is occasionally present.
Treatment and prognosis
Prognosis is considered to be poorer as compared to germinomas 4. A combination of surgical resection, chemotherapy and radiotherapy is recommended 4.
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- 2. Al-Masri A, Khasawneh N, Aladily T. Unusual Anatomic Location of a Primary Intracranial Yolk Sac Tumor. Ann Saudi Med. 2011;31(3):298-300. doi:10.4103/0256-4947.76410 - Pubmed
- 3. Kurisaka M, Moriki A, Mori K, Sonobe H. Primary Yolk Sac Tumor in the Spinal Cord. Childs Nerv Syst. 1998;14(11):653-7. doi:10.1007/s003810050293 - Pubmed
- 4. Gaoyu C, Deyu G, Zhi C, Hua F. Yolk Sac Tumor in the Fourth Ventricle: A Case Report. Clin Neurol Neurosurg. 2009;111(7):636-7. doi:10.1016/j.clineuro.2009.05.009 - Pubmed