Intrahepatic cholangiocarcinoma (staging - AJCC/UICC 8th edition)

Dr Henry Knipe and Dr Laurent Bilodeau et al.

The American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) introduced a unique staging system for the intrahepatic cholangiocarcinoma in their 7th edition in 2010. They further refined the staging system in the 8th edition.

TNM system

T: primary tumor

  • Tx: primary tumor cannot be assessed 
  • T0: no evidence of a primary tumor
  • T1 
    • T1a: solitary tumor ≤5 cm without vascular invasion
    • T1b: solitary tumor >5 cm without vascular invasion​
  • T2: 
    • solitary tumor with intrahepatic vascular invasion or,
    • multiple tumors, with or without vascular invasion​
  • T3: tumor perforating the visceral peritoneum
  • T4: tumor involving local extrahepatic structures by direct invasion

N: regional lymph node involvement

  • Nx: regional lymph nodes cannot be assessed
  • N0: no regional lymph node metastasis
  • N1: regional lymph node metastasis present

M: distant metastasis

  • M0: no distant metastasis
  • M1: distant metastasis present
Stage groupings
  • stage Ia
    • TNM equivalent: T1a, N0, M0
    • 5-year survival: 58%
  • stage Ib
    • TNM equivalent: T1b, N0, M0
    • 5-year survival: 45%
  • stage II
    • TNM equivalent: T2, N0, M0
    • 5-year survival: 31%
  • stage IIIa
    • TNM equivalent: T3, N0, M0 
    • 5-year survival: 24%
  • stage IIIb
    • TNM equivalent: T4 and/or N1, M0
  • stage IV
    • TNM equivalent: any T, any N with M1
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Article information

rID: 72246
Section: Staging
Synonyms or Alternate Spellings:

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