Intramembranous ossification

Dr Henry Knipe and Dr Pamela Mayhew et al.

Intramembranous ossification describes the process of ossification from mesenchymal cells (stem cells) without a cartilaginous template and is involved in the healing process of fractures. The stages of intramembranous ossification osteogenesis are as follows:

  • mesenchymal cells differentiate into osteoblasts
  • osteoblasts deposit matrix which becomes mineralized
  • immature woven trabeculae (primary spongiosa) is deposited
  • primary spongiosa is replaced by secondary bone
    • bone marrow formation
    • primary cortical bone

Gross anatomy

Seen in the formation of:

Anatomy: General

Article information

rID: 44008
Section: Anatomy
Tag: refs
Synonyms or Alternate Spellings:

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