Intravascular (blood pool) MRI contrast agents
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At the time the article was created J. Ray Ballinger had no recorded disclosures.View J. Ray Ballinger's current disclosures
At the time the article was last revised Andrew Murphy had no recorded disclosures.View Andrew Murphy's current disclosures
Intravascular MRI contrast agents normally remain confined to the intravascular space, compared to Gd-DTPA which distributes throughout the extracellular fluid space. This is a result of intravascular agents having a molecular weight of approximately 70,000 and above, compared to a molecular weight of 590 for Gd-DTPA.
There are several advantages of intravascular agents:
- they can assess perfusion in areas of ischemia and provide information about capillary permeability in areas of reperfusion
- they can show the extent of tumor neovascularity and associated permeability changes
- they are useful in studies requiring prolonged imaging.
These types of intravascular contrast agents will be discussed separately: