Intussusception occurs when one segment of bowel is pulled into itself (or a neighbouring loop of bowel) by peristalsis.
It is an important cause of an acute abdomen in children and merits timely ultrasound examination and reduction to preclude significant sequelae including bowel necrosis.
Intussusception may also occur in the adult population where it is usually caused by a focal lesion acting as a lead point.
The vast majority of intussusceptions occur in children (95%), usually after the first three months of life 13.
While the classic triad of intermittent abdominal pain, vomiting and right upper quadrant mass, plus occult or gross blood on rectal examination has great positive predictive value for intussusception in children 1, these findings are seen in less than 20% of intussusception cases 2. Approximately 15% (range 13-22%) of patients with intussusception do not even present with abdominal pain 3,4.
A proximal part of bowel is pulled into the distal lumen and propulsed forwards as it were a bolus of food. The prolapsing part of the bowel is described as the intussusceptum while the distal segment of bowel receiving the intussusceptum is described as the intussuscipiens. As the mesentery is incorporated into the intussusception, venous return is compromised resulting in oedema and further restriction to blood flow. Eventually, arterial supply to the bowel is interrupted and ischaemia and necrosis ensue.
In children, no lead point can usually be identified (90%) and this is most frequently thought to relate to enlarged lymphoid tissue following an infection. This potentially explains the relative rarity of the condition in the first three months of life, when passive immunity is still paramount.
In infants or adults, a lead point is more frequently identified (up to 90% of the time in adults, usually malignant in the large bowel and benign in the small bowel 13). Lead points are numerous and include 9,11,13:
- gastrointestinal malignancy (most common cause in adults, accounting for 65% of cases 13)
- benign neoplasms
- mural haematoma
Intussusception can occur essentially anywhere. In adults, no such distribution is present as in the vast majority of cases a lead point lesion is present, and thus the location will depend on the location of that lesion. In children there is a strong predilection for the ileocolic region:
- ileocolic: most common (75-95%), presumably due to the abundance of lymphoid tissue related to the terminal ileum and the anatomy of the ileocaecal region
- ileoileocolic: second most common
- ileoileal and colocolic: uncommon
- gastric intussusception: rare, but documented 13
Abdominal x-rays may demonstrate an elongated soft tissue mass (typically in the upper right quadrant in children) with a bowel obstruction (and therefore air-fluid levels and bowel dilation) proximal to it. There may be an absence of gas in the distal collapsed bowel.
Ultrasonography has a false-negative rate approaching zero and is a reliable screening tool for children at low risk for intussusception 5-9. Children with classic findings of intussusception, however, need to be investigated with contrast enema, which is both diagnostic (the gold standard in the diagnosis of intussusception) and therapeutic.
Ultrasound signs include:
A contrast enema remains the gold standard, demonstrating the intussusception as an occluding mass prolapsing into the lumen, giving the "coiled spring” appearance (barium in the lumen of the intussusceptum and in the intraluminal space). The main contraindication for an enema is a perforation.
CT has become the modality of choice for assessment of acute abdomen in adults, and thus most frequently images intussusception. Also, short length transient intussusception is a frequent incidental finding.
The appearance of intussusception on CT is characteristic and depends on the imaging plane and where along the bowel images are obtained.
Best know is the so-called bowel-within-bowel configuration, in which the layers of the bowel are duplicated forming concentric rings (CT equivalent of the ultrasonographic target sign) when imaged at right angles to lumen, and a soft tissue sausage when imaged longitudinally 13.
At the proximal end of the intussusception, there will be two concentric enhancing/hyperdense rings, formed by the inner bowel and the folded edge of the outer bowel. As one images further along the intussusception the mesentery (fat and vessels) will form a crescent of tissue around the compressed innermost lumen, surrounded by the two layers of the outer enveloping bowel. Even further distally the lead point (if present) will be visualised 13.
Treatment and prognosis
In children, intussusception reduction can be achieved without recourse to surgery in most cases. Using a water soluble medium or air, retrograde pressure can be exerted to reduce the intussusception. If symptoms have been protracted, rectal blood is present, there are signs of peritonitis or enema reduction is unsuccessful then surgical intervention is usually required. With no surgical treatment, there can be recurrence rates of up to 30%.
In adults, a laparotomy is usually required, especially as in most cases a lead point requiring treatment is present.
On imaging the appearances on ultrasound and CT are characteristic. The main differential is that of transient intussusception, which is an incidental finding requiring no treatment or follow-up.
Other conditions to be considered in adults include:
- 1. Harrington L, Connolly B, Hu X et-al. Ultrasonographic and clinical predictors of intussusception. J. Pediatr. 1998;132 (5): 836-9. J. Pediatr. (link) - Pubmed citation
- 2. Ein SH, Stephens CA, Minor A. The painless intussusception. J. Pediatr. Surg. 1976;11 (4): 563-4. J. Pediatr. Surg. (link) - Pubmed citation
- 3. Kuppermann N, O'Dea T, Pinckney L et-al. Predictors of intussusception in young children. Arch Pediatr Adolesc Med. 2000;154 (3): 250-5. Arch Pediatr Adolesc Med (link) - Pubmed citation
- 4. Swischuk LE, Hayden CK, Boulden T. Intussusception: indications for ultrasonography and an explanation of the doughnut and pseudokidney signs. Pediatr Radiol. 1985;15 (6): 388-91. Pubmed citation
- 5. Lee HC, Yeh HJ, Leu YJ. Intussusception: the sonographic diagnosis and its clinical value. J. Pediatr. Gastroenterol. Nutr. 1989;8 (3): 343-7. Pubmed citation
- 6. Friedman AP, Haller JO, Schneider M et-al. The pediatric corner. Sonographic appearance of intussusception in children. Am. J. Gastroenterol. 1979;72 (1): 92-4. Pubmed citation
- 7. Bhisitkul DM, Listernick R, Shkolnik A et-al. Clinical application of ultrasonography in the diagnosis of intussusception. J. Pediatr. 1992;121 (2): 182-6. Pubmed citation
- 8. Pracros JP, Tran-Minh VA, Morin de Finfe CH et-al. Acute intestinal intussusception in children. Contribution of ultrasonography (145 cases). Ann Radiol (Paris). 1987;30 (7): 525-30. Pubmed citation
- 9. Sparnon AL, Little KE, Morris LL. Intussusception in childhood: a review of 139 cases. Aust N Z J Surg. 1984;54 (4): 353-6. Pubmed citation
- 10. Anderson DR. The pseudokidney sign. Radiology. 1999;211 (2): 395-7. Radiology (full text) - Pubmed citation
- 11. del-Pozo G, Albillos JC, Tejedor D. Intussusception: US findings with pathologic correlation--the crescent-in-doughnut sign. Radiology. 1996;199 (3): 688-92. Radiology (abstract) - Pubmed citation
- 12. Kim YH, Blake MA, Harisinghani MG et-al. Adult intestinal intussusception: CT appearances and identification of a causative lead point. Radiographics. 26 (3): 733-44. doi:10.1148/rg.263055100 - Pubmed citation
- 13. Choi SH, Han JK, Kim SH et-al. Intussusception in adults: from stomach to rectum. AJR Am J Roentgenol. 2004;183 (3): 691-8. AJR Am J Roentgenol (citation) - Pubmed citation