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Invasive ductal carcinoma

Invasive ductal carcinoma not otherwise specified, also known as invasive carcinoma of no special type, is the most common type of breast cancer. It is an infiltrating, malignant and abnormal proliferation of neoplastic cells in the breast tissues.

The latest (4th) edition of the World Health Organization classification of tumors of the breast changed the preferred terminology from invasive ductal carcinoma, not otherwise specified (NOS) to invasive (breast) carcinoma of no special type (NST) 4. The rationale is that the use of 'ductal' relies on unproven histogenetic assumptions for this heterogeneous group of cancers. Invasive ductal carcinoma or ductal NOS remains acceptable and commonly used terms. 

Peak age of presentation is about 50 to 60 years.

Large palpable, immobile mass.

  • ill-defined lesion
  • hypoechoic mass
  • hyperechoic angular margins
  • posterior acoustic shadowing
  • ductal extension may be seen which is extension of the lesion into surrounding parenchyma
  • branched or spiculated pattern
  • microcalcifications
  • T1
    • isointense to parenchyma
    • hypointense to fat
  • T1 C+ (Gd)
    • ring enhancement with centripetal progression
    • dilated veins draining the tumor
  • T2
    • iso to hypointense to parenchyma
    • hyperintense edematous zone
Breast imaging and pathology

Article information

rID: 29143
System: Breast, Oncology
Synonyms or Alternate Spellings:
  • Carcinoma NST (breast)
  • Invasive mammary carcinoma of no special type
  • IDC NOS
  • Invasive breast carcinoma of no special type
  • Infiltrating ductal carcinoma

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Cases and figures

  • Figure 1: histology
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  • Case 1
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  • Case 2
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  • Case 3
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  • Case 4
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  • Case 5
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  • Case 6
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  • Case 7: recurrence at mastectomy site
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  • Case 8: CT
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  • Case 9
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