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Iodide mumps is a rare adverse reaction to iodinated contrast media. Both ionic and non-ionic contrast agents can cause these reactions, but about 90% of the cases occur with the former.
The incidence is unknown, but this condition is likely underdiagnosed due to limited awareness. Prompt clinical recognition is essential so that further unnecessary investigation and cross-sectional imaging can be avoided.
The pathophysiology is poorly understood and may be due to a hypersensitivity reaction or, more likely, the toxic accumulation of contrast in the salivary gland ducts. The salivary glands have been shown to concentrate contrast levels up to 100 times that of serum values post-administration. 2 Contrast is excreted nearly exclusively by the kidneys, and it has been hypothesized that pre-existing renal impairment may predispose to this condition. However, this correlation was not demonstrated in a recent meta-analysis. 3
Patients can present within minutes to several days after contrast administration, with painless salivary gland swelling. The submandibular and/or parotid glands are affected, however, there is a case report of sublingual gland disease. 4 The presentation can be similar to calculous or infectious sialadenitis.
Ultrasound is the imaging modality of choice, which can exclude an obstructing calculus and demonstrate the typically bilateral process.
The affected glands appear enlarged and hypervascular, with prominent internal hypoechoic septae. The glands may also demonstrate a thin surrounding layer of fluid. 5
Treatment and prognosis
This self-limiting adverse reaction is managed conservatively and usually spontaneously subsides after about 24 hours. Medications such as steroids and antihistamines have not been shown to be effective. 3
- 1. Si Chen, Benjamin C. Paul, David Myssiorek. An Algorithm Approach to Diagnosing Bilateral Parotid Enlargement:. (2013) Otolaryngology--Head and Neck Surgery. 148 (5): 732-9. https://doi.org/10.1177/0194599813476669
- 2. Talner, Lee B., et al. "Elevated salivary iodine and salivary gland enlargement due to iodinated contrast media." American Journal of Roentgenology 112.2 (1971): 380-382
- 3. Jiao A, Farsad K, McVinnie DW, Jahangiri Y, Morrison JJ. Characterization of Iodide-induced Sialadenitis: Meta-analysis of the Published Case Reports in the Medical Literature. Acad Radiol. 2020;27(3):428-435. doi:10.1016/j.acra.2019.05.006
- 4. Park, Ki Wan et al. “Contrast-Induced Sialadenitis of the Sublingual Glands.” Case reports in otolaryngology vol. 2020 8851382. 8 Sep. 2020, doi:10.1155/2020/8851382
- 5. Longo C, De Robertis R, Valdo M, Montemezzi S. A case of acute bilateral iodine-induced submandibular sialadenitis: Ultrasound findings. J Clin Ultrasound. 2022;50(1):70-73. doi:10.1002/jcu.23049