Ioflupane (I-123)

Last revised by Dr Ian Bickle on 28 Dec 2021

Ioflupane (I-123) is a radiopharmaceutical for the diagnosis of Parkinson disease and its differential diagnoses: essential tremor versus tremor due to parkinsonian syndromes (idiopathic Parkinson disease, multiple system atrophy and progressive supranuclear palsy). 

  • iodine-123 is a cyclotron product
  • decay by electron capture to tellurium-123
  • physical half-life is 13.22 hours
  • predominant energy of its gamma spectrum is 159 keV

Ioflupane is the international non-proprietary name of a phenyltropane compound, usually abbreviated to FCPIT (fluoropropyl beta-carbomethoxy-3 beta-(4-iodophenyltropane), a cocaine analog. Ioflupane has a high affinity for presynaptic dopamine transporters (DAT) which are abundant in the striatal region.

I-123 ioflupane is available worldwide and marketed under the trade name DaTSCANTM.

  • as a cyclotron product, the solution is supplied ready to inject
  • the dose reference activity of I-123 ioflupane is 185 MBq (5 mCi)
  • administration is intravenous
  • thyroid blocking with 120 mg potassium iodide 2 hours before and 24 hours after the injection is recommended
  • SPECT is typically performed 3-6 hours after injection

Reduced putaminal uptake as evidenced visually by the loss of the normal comma- or crescent-shaped uptake in the striatum and the appearance of abnormal period- or oval-shaped uptake in the caudate only is supportive of a diagnosis of a parkinsonian syndrome:

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Cases and figures

  • Normal DaT (I-123 Ioflupane) scan
    Drag here to reorder.
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