Citation, DOI, disclosures and article data
At the time the article was created Fabio Macori had no recorded disclosures.View Fabio Macori's current disclosures
At the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.View Henry Knipe's current disclosures
The ADNEX (Assessment of Different NEoplasias in the adneXa) model is a risk model developed by the IOTA (International Ovarian Tumor Analysis) group to differentiate benign and malignant neoplasms of the ovary and, among them, four different subgroups (borderline, stage I cancer, stage II-IV cancer, and secondary metastatic cancer).
The model uses nine different predictors, three clinical and six ultrasound variables with an online calculator available.
serum CA-125 level
the type of center (oncology centers vs other hospitals)
maximum diameter of the lesion
the proportion of solid tissue
more than ten cyst locules
number of papillary projections
History and epidemiology
The ADNEX model was developed in 2014 by the IOTA group. In contrast to existing models (e.g., IOTA ultrasound rules for ovarian masses), which only allowed differential diagnosis between benign and malignant neoplasms of the ovary, this model also assesses the stage of the disease. This is important because a correct characterization of the lesion allows different lesion management.
- Van Calster B, Van Hoorde K, Valentin L et al. Evaluating the Risk of Ovarian Cancer Before Surgery Using the ADNEX Model to Differentiate Between Benign, Borderline, Early and Advanced Stage Invasive, and Secondary Metastatic Tumours: Prospective Multicentre Diagnostic Study. BMJ. 2014;349(oct07 3):g5920. doi:10.1136/bmj.g5920 - Pubmed
- Gaurilcikas A, Gedgaudaite M, Cizauskas A et al. Performance of the IOTA ADNEX Model on Selected Group of Patients with Borderline Ovarian Tumours. Medicina. 2020;56(12):690. doi:10.3390/medicina56120690 - Pubmed
- Jeong S, Park B, Lee Y, Kim T. Validation of IOTA-ADNEX Model in Discriminating Characteristics of Adnexal Masses: A Comparison with Subjective Assessment. JCM. 2020;9(6):2010. doi:10.3390/jcm9062010 - Pubmed
- Van Calster B, Van Hoorde K, Froyman W et al. Practical Guidance for Applying the ADNEX Model from the IOTA Group to Discriminate Between Different Subtypes of Adnexal Tumors. Facts Views Vis Obgyn. 2015;7(1):32-41. PMC4402441 - Pubmed